Both from the perspective of narrative and of game design, McMillen built The Binding of Isaac around the Biblical story of Genesis 22:1-19, which has the same name in Jewish and Christian tradition, but he placed it in a modern-day setting in which a young boy is endangered by a mentally disturbed mother who hears “voices from above” that instruct her to sacrifice her only child. Isaac is a roguelike dungeon crawler with randomly generated dungeons. The game The Binding of Isaac is an excellent example of a game that incorporates criticism of religion.
